ea0016p516 | Obesity | ECE2008
Salome N
, Gustafsson L
, Taube M
, Hansson C
, Karlsson L
, Fehrentz JA
, Martinez J
, Perrissoud D
, Dickson SL
Central treatment with ghrelin increases body weight and fat accumulation. Here we explore the pharmacological effect of a combined central (ICV) infusion of ghrelin (0.3 nmol/day) and a recently developed ghrelin receptor (GHS-R1A) antagonist (JMV2959, 100 nmol/day) on food intake and body composition. The effect of ghrelin infusion for 14 days to increase body weight (20.7±0.9% vs 34.3±3.1%, saline vs ghrelin, P<0.001) was blocked by co-infusion with JMV...